HiCOMB 2009
Eighth IEEE International Workshop on High Performance Computational Biology

Monday, May 25, 2009
Rome, Italy

(Held in conjunction with the International Parallel and Distributed Processing Symposium)

HiCOMB Online Proceedings

Advance Program for HiCOMB 2009

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(Please note that the IPDPS 2009 registration includes access to this workshop, and that there is no separate workshop registration).

HiCOMB 2009 Keynote Talk

De Novo Modeling of GPCR Class A Structures

Charles L. Brooks III
University of Michigan, Ann Arbor

In this talk I will describe recent work to develop novel methods to model GPCR structures from their sequence information and statistically significant side chain contacts within a "template" structure. Our approach utilizes methods of bioinformatics to identify likely high confidence side chain side chain TM helical contacts and then reconstitutes the seven TM helical domain through a simulated annealing protocol with refinement using replica exchange and an implicit solvent/implicit membrane sampling scheme. Results will be presented for de novo prediction of the b2 adenergic receptor, the adenine receptor and a number of other amine receptors.

Speaker Biography:
Charles L. Brooks III is the Warner-Lambert Professor of Chemistry and Professor of Biophysics at the University of Michigan. Prior to moving to Michigan in 2008, Professor Brooks was professor of Molecular Biology at The Scripps Research Institute since 1994 and professor of Chemistry at Carnegie Mellon University until 1993, where he began as an assistant professor in 1985. Professor Brooks received his undergraduate training in chemistry, physics and mathematics from Alma College. He studied chemical physics at Purdue University, where he received his Ph.D. in 1982, and was a postdoctoral fellow at Harvard University from 1982-85. Professor Brooks' research focuses on the applications of statistical mechanics, quantum chemistry, and computational methods to solve chemically and physically oriented problems in biology.

Papers to be presented at HiCOMB 2009:

HiCOMB 2009 Call For Papers

Computational Biology is fast emerging as an important discipline for academic research and industrial application. The large size of biological data sets, inherent complexity of biological problems and the ability to deal with error-prone data all result in large run-time and memory requirements. The goal of this workshop is to provide a forum for discussion of latest research in developing high-performance computing solutions to problems arising from molecular biology. We are especially interested in parallel algorithms, memory-efficient algorithms, large scale data mining techniques, and design of high-performance software. The workshop will feature contributed papers as well as invited talks from reputed researchers in the field.

Topics of interest include but are not limited to:

Submission guidelines:

Papers reporting on original research (both theoretical and experimental) in all areas of bioinformatics and computational biology are sought. Surveys of important recent results and directions are also welcome. To submit a paper, upload a postscript or PDF copy of the paper here. The paper should not exceed 12 single-spaced pages (US Letter or A4 size) in 11pt font or larger. All papers will be reviewed. IEEE CS Press will publish the IPDPS symposium and workshop abstracts as a printed volume. The complete symposium and workshop proceedings will also be published by IEEE CS Press on CD-ROM and will also be available in the IEEE Digital Library.

Important Dates

Workshop Paper Due: November 30, 2008 (Extended Deadline)
Author Notification: December 25, 2008
Camera-ready Paper Due: February 15, 2009

Workshop Co-Chairs

Srinivas Aluru
Dept. of Electrical & Computer Engg. and
Lawrence H. Baker Center for Bioinformatics
         & Biological Statistics
Iowa State University
3227 Coover Hall
Ames, IA 50011, USA
Phone: +1.515.294.3539
David A. Bader
College of Computing
Georgia Institute of Technology
Atlanta, GA 30332 USA
Phone: +1.404.894.3152

Program Chair

Michela Taufer
Dept. of Computer and Information Sciences
University of Delaware
103 Smith Hall
Newark, DE 19716 USA
Phone: +1.302.831.0071

Program Committee

For up-to-date information about this workshop, please visit http://www.hicomb.org/.

Call for Papers for HiCOMB 2009:

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