HiCOMB 2009
Eighth IEEE International Workshop on High Performance Computational Biology

Monday, May 25, 2009
Rome, Italy

(Held in conjunction with the International Parallel and Distributed Processing Symposium)


HiCOMB Online Proceedings

Advance Program for HiCOMB 2009

Register Online

(Please note that the IPDPS 2009 registration includes access to this workshop, and that there is no separate workshop registration).

HiCOMB 2009 Keynote Talk

De Novo Modeling of GPCR Class A Structures

Charles L. Brooks III
University of Michigan, Ann Arbor

Abstract:
In this talk I will describe recent work to develop novel methods to model GPCR structures from their sequence information and statistically significant side chain contacts within a "template" structure. Our approach utilizes methods of bioinformatics to identify likely high confidence side chain side chain TM helical contacts and then reconstitutes the seven TM helical domain through a simulated annealing protocol with refinement using replica exchange and an implicit solvent/implicit membrane sampling scheme. Results will be presented for de novo prediction of the b2 adenergic receptor, the adenine receptor and a number of other amine receptors.

Speaker Biography:
Charles L. Brooks III is the Warner-Lambert Professor of Chemistry and Professor of Biophysics at the University of Michigan. Prior to moving to Michigan in 2008, Professor Brooks was professor of Molecular Biology at The Scripps Research Institute since 1994 and professor of Chemistry at Carnegie Mellon University until 1993, where he began as an assistant professor in 1985. Professor Brooks received his undergraduate training in chemistry, physics and mathematics from Alma College. He studied chemical physics at Purdue University, where he received his Ph.D. in 1982, and was a postdoctoral fellow at Harvard University from 1982-85. Professor Brooks' research focuses on the applications of statistical mechanics, quantum chemistry, and computational methods to solve chemically and physically oriented problems in biology.


Papers to be presented at HiCOMB 2009: