HiCOMB 2005
Fourth IEEE International Workshop on High Performance Computational Biology

Monday, April 4, 2005
Omni Interlocken Resort, Denver, CO

(Held in conjunction with the International Parallel and Distributed Processing Symposium)


HiCOMB Online Proceedings

Advance Program for HiCOMB 2005

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(Please note that the IPDPS 2005 registration includes access to this workshop, and that there is no separate workshop registration).

HiCOMB 2005 Keynote Talk

Folding@Home: Advances in biophysics and biomedicine from world-wide grid computing

Vijay Pande
Stanford University

Simulations of biological molecules offers a lot of promise to complement and extend current experiments in the areas of biophysics and biomedicine. However, there are some serious limitations that must be overcome before computational methods are universally accepted. For example, one must be able to examine timescales that are thousands to billions of times longer than most typical simulations. How can one surmount such fundamental computational barriers? I will discuss our solutions to this problem, which combine novel physical chemistry theory and computational paradigms. In addition, I will discuss recent applications of these methods to fundamental questions in biophysics and biomedical applications, including protein folding, protein-protein association, protein-ligand binding, and protein misfolding & aggregation.

Speaker Biography:
Prof. Pande's current research centers on the development and application of novel grid computing simulation techniques to address problems in chemical biology. In particular, he has pioneered novel distributed computing methodology to break fundamental barriers in the simulation of kinetics and thermodynamics of proteins and nucleic acids. As director of the Folding@Home project, Prof. Pande has, for the first time, directly simulated protein folding dynamics with quantitative comparisons with experiment, often considered a "holy grail" of computational biology. His current research also includes novel simulation methods for high precision drug binding affinity calculations, protein design, and synthetic bio-mimetic polymers.

Prof. Pande received a BA in Physics Princeton University in 1992. There, he was first introduced to biophysical questions, especially in his undergraduate thesis research with Prof. Philip Anderson, a Nobel Laureate in physics. In 1995, he received his PhD in physics from MIT, studying as a NSF Fellow under Profs. Toyoichi Tanaka and Alexander Grosberg. At MIT, Prof. Pande's research centered on statistical mechanical models of protein folding and design, suggesting novel ways to design protein sequences to have the desired stability and folding properties. As a Miller Fellow working with Prof. Daniel Rokhsar at UC Berkeley, Prof. Pande extended this methodology to examine atomistic protein models, laying the foundations for his later work at Stanford University.

Prof. Pande has won numerous awards, including most recently being named to MIT'S TR100 (top young innovators in 2002), a Frederick E. Terman Fellowship (2002), and a Henry and Camile Dreyfus Teacher-Scholar (2003). Prof. Pande is currently an Assistant Professor of Chemistry and (by courtesy) of Structural Biology.

Papers to be presented at HiCOMB 2005:

HiCOMB 2005 Call For Papers

Computational Biology is fast emerging as an important discipline for academic research and industrial application. The large size of biological data sets, inherent complexity of biological problems and the ability to deal with error-prone data all result in large run-time and memory requirements. The goal of this workshop is to provide a forum for discussion of latest research in developing high-performance computing solutions to problems arising from molecular biology. We are especially interested in parallel algorithms, memory-efficient algorithms, large scale data mining techniques, and design of high-performance software. The workshop will feature contributed papers as well as invited talks from reputed researchers in the field.

Topics of interest include but are not limited to:

Submission guidelines:

Papers reporting on original research (both theoretical and experimental) in all areas of bioinformatics and computational biology are sought. Surveys of important recent results and directions are also welcome. To submit a paper, send a postscript or PDF copy of the paper by email to the workshop's Program Chair, Prof. Nancy Amato <amato@cs.tamu.edu>. The paper should not exceed 12 single-spaced pages (US Letter or A4 size) in 11pt font or larger. All papers will be reviewed. IEEE CS Press will publish the IPDPS symposium and workshop abstracts as a printed volume. The complete symposium and workshop proceedings will also be published by IEEE CS Press on CD-ROM and will also be available in the IEEE Digital Library.

Authors of selected papers from the workshop will be invited to submit extended versions of their papers for publication in a special issue of IEEE Transactions on Parallel and Distributed Systems on High-Performance Computational Biology.

Important Dates

Workshop Paper Due: November 15, 2004
Author Notification: December 15, 2004
Camera-ready Paper Due: January 21, 2005

Workshop Co-Chairs

David A. Bader
Electrical & Computer Engr. Dept.
University of New Mexico
Albuquerque, NM 87131 USA
Phone: +1.505.277.6724
Fax: +1.505.277.1439
Email: dbader@ece.unm.edu
Srinivas Aluru
Dept. of Electrical & Computer Engg. and
Lawrence H. Baker Center for Bioinformatics
         & Biological Statistics
Iowa State University
3218 Coover Hall
Ames, IA 50011, USA
Phone: +1.515.294.3539
Fax: +1.515.294.8432
email: aluru@iastate.edu

Program Chair

Nancy M. Amato
Parasol Laboratory
Department of Computer Science
Texas A&M University
College Station, TX 77843-3112 USA
Phone: +1 979-862-2275
Fax: +1 979-458-0718
Email: amato@cs.tamu.edu

Program Committee

For up-to-date information about this workshop, please visit http://www.hicomb.org/.

Call for Papers for HiCOMB 2005:

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Last updated: Wed Feb 9 21:58:20 MST 2005