HiCOMB Online Proceedings

Advance Program for HiCOMB 2004

HiCOMB 2004 Keynote Talk

Three-Dimensional Reconstruction of Viruses: Challenges and Strategies

Viruses are cellular parasites. A deeper understanding of many aspects of viral life cycles has emerged from coordinated molecular and structural studies carried out with a wide range of viral pathogens. Structural studies of viruses by means of transmission electron cryo-microscopy (cryo-EM), 3D image reconstruction, and pseudo-atomic modeling methods have grown explosively in the last decade. These methods have been successfully employed in the investigation of a wide range of icosahedral viruses, ranging in size from as small as 30nm to larger than 200nm. The talk will review the current technologies involved in obtaining 3D structural information on viruses and briefly highlight some recent results at better than 10 Å resolution on both enveloped and non-enveloped icosahedral viruses. Numerous technological obstacles stand in the path of obtaining near atomic resolution (0.4 nm or better) structural data on symmetric as well as non-symmetric viruses. Particular emphasis will be devoted to describing the development of new computational tools designed to provide high throughput data analysis at high resolution.

Papers to be presented at HiCOMB 2004:

• Study of a Highly Accurate and Fast-Protein Ligand Docking Algorithm Based Upon Molecular Dynamics
  M. Taufer, M. Crowley, D. Price, A.A. Chien, and C. L. Brooks III
• Parallel Protein Folding with STAPL
  S. Thomas and N. Amato
• A Hypergraph Model for the Yeast Protein Complex Network
  E. Ramadan, A. Tarafdar, and A. Pothen
• Dynamic Programming for LR-PCR Segmentation of Bacterium Genomes
  R. Andonov, D. Lavenier, N. Yanev, and P. Veber
• Parallel RNA Sequence-Structure Alignment
  T. Liu and B. Schmidt
• Constrained De Novo Peptide Identification via Multiobjective Optimization
  J.M. Mallard, A. Heredia-Langner, D.J. Baxter, K.H. Jarman, and W. R. Cannon
• Identification of Mycobacteriun Species Using Curated Custom Databases
  D. Kuyper, H. Ali, A.M. Mohamed, and S.H. Hinrichs
• High Performance Computational Tools for Motif Discovery
  N.E. Baldwin, R.L. Collins, M. A. Langston, M.R. Leuze, C.T. Symons, and B. H. Voy
• High Performance Biosequence Database Scanning on Reconfigurable Platforms
  T. Oliver and B. Schmidt
• New Fast and Acurate Heuristics for Inference of Large Phylogenic Trees
  A.P. Stamatakis, T. Ludwig, and H. Meier
• Large-Scale Simulation of Eukaryotic Cell Signaling Processes
  J.H. Miller and F. Zheng
• Particle Swarm Optimization and Neural Network Application for QSAR
  Z. Wang, G.L. Durst, R.C. Eberhart, D.B. Boyd, and Z. Ben Miled

Workshop Co-Chairs
 

David A. Bader Electrical & Computer Engr. Dept. University of New Mexico Albuquerque, NM 87131 USA Phone: +1.505.277.6724 Fax: +1.505.277.1439 Email: dbader@ece.unm.edu

Srinivas Aluru Dept. of Electrical & Computer Engg. and Lawrence H. Baker Center for Bioinformatics          & Biological Statistics Iowa State University 3218 Coover Hall Ames, IA 50011, USA Phone: +1.515.294.3539 Fax: +1.515.294.8432 email: aluru@iastate.edu

Program Chair
 

Dan C. Marinescu Computer Science Department University of Central Florida 4000 Central Florida Boulevard Orlando, Florida, 32816, USA Phone: +1 407 823 4860 FAX: +1 407 823 5419 Email: dcm@cs.ucf.edu http://www.cs.ucf.edu/~dcm

Program Committee
 

Prof. Alberto Apostolico Computer Sciences Department Purdue University West Lafayette, IN, 47907 Email: axa@cs.purdue.edu http://www.cs.purdue.edu/people/axa Phone: +1.765.494.6015

Prof. Concettina Guerra Dip. Ingegneria dell'Informazione Universita'di Padova via Gradenigo 6a, 35100, Padova, Italy Email: guerra@dei.unipd.it http://www.dei.unipd.it/~guerra Phone: +39 049 827 7933

Prof. Wojciech Szpankowski Computer Sciences Department Purdue University West Lafayette, IN, 47907 Email: spa@cs.purdue.edu http://www.cs.purdue.edu/people/spa Phone: +1.765.494.6703

For up-to-date information about this workshop, please visit http://www.hicomb.org/.